GalNAc-siRNA conjugates

by cailynn on Mar 6th, 2025 07:55 AM

GalNAc-siRNA conjugates are a revolutionary tool in RNA interference (RNAi) therapy, enabling targeted delivery of small interfering RNA (siRNA) to liver cells. By leveraging the specific binding of GalNAc to asialoglycoprotein receptors, these conjugates enhance cellular uptake and therapeutic efficacy. They are widely used in treating liver-related diseases, such as hepatitis, hypercholesterolemia, and genetic disorders. The development of GalNAc-siRNA conjugates has significantly advanced precision medicine, offering potent and specific gene-silencing solutions with minimal off-target effects.