anti-Thyroglobulin CAR-T in vivo assay

by cataliesw on Oct 22nd, 2024 11:16 AM

Thyroglobulin (Tg) is a 660 kDa glycoprotein homodimer, which is produced predominantly by the follicular cells (thyrocytes) of the thyroid gland and ultimately metabolized within the liver. Physiologically, Tg acts as a substrate for the synthesis of thyroid hormones like thyroxine (T4) and triiodothyronine (T3). Meanwhile, Tg accounts for approximately half of the protein content of the thyroid gland and the breakdown of Tg releases iodine, so it also functions as storage of the inactive form of iodine for breast, stomach, salivary glands, thymus, choroid plexus and cerebrospinal fluid, etc. Normally, Tg is mainly located in the thyroid gland and circulating between the thyroid gland and the liver via blood. More details about anti-Thyroglobulin CAR-T in vivo assay